Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.

Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis.

OBJECTIVE We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. METHODS We searched for controlled observational studies comparing SSRI therapy with a control group not receiving SSRIs. We used DerSimonian and Laird fixed effect models to compute summary risk associations. RESULTS Intracranial hemorrhage w...

Meta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients

This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability.

BACKGROUND A meta-analysis of the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried out. METHODS Efficacy data from 102 randomised controlled trials (10706 patients) were pooled to provide a summary variance-weighted effect size. Tolerability data from 95 studies (10553 patients) were combine...

Selective serotonin reuptake inhibitors.